FPC/SFPC系列多功能流化床

The FPC/SFPC series Muti-Functional Fluid Bed

 

FPC/SFPC系列多功能流化床除满足各种常规物料制粒及包衣作用外,最突出的优势是可以实现100um以下粉末包衣,离心力的加入, 可以抵消微粒子间的内聚力,同时提升微粒子初始动能,从原理上优化微粒子流化状态,提高包衣产品质量,满足微小粒子包衣同时避 免团聚效应的需求。

 

 

The FPC/SFPC series multifunction fluid bed, in addition to meeting the granulation and coating requirements of conventional materials, is capable of achieving stable coating of fine powders below 100 μm. The introduction of centrifugal acceleration reduces the influence of interparticle cohesive forces while enhancing particle momentum and circulation dynamics. As a result, the fluidization quality of microparticles is significantly improved, leading to enhanced coating uniformity and minimized agglomeration. 

 

01.设备优势 Advantages

 

1.粉末包衣

Powder Coating

 

可以实现对100um以下的粉末的包衣

Capable of coating powders below 100 μm.

 

优异的衣膜质量和溶出结果

Excellent film quality and dissolution results.

 

更高的产品收率

Higher product yield.

 

减少或杜绝了有机溶剂的使用

Reduces or eliminates the use of organic solvents.

 

2.湿法滚圆包衣 

Wet Granulation Spheronization & Coating

 

高堆密度和高圆整度球形颗粒

Produces spherical granules with high bulk density and high sphericity.

 

颗粒圆整度更高,且适合后续加工处理

Granules achieve superior sphericity, making them suitable for subsequent processing.

 

同一丸芯上实现多种活性成分的多层包衣

Enables multi-layer coating of multiple active ingredients on the same pellet core.

 

可使用的丸芯包括空白丸芯(蔗糖,MCC丸芯)的丸芯

Compatible pellet cores include nonpareil seeds (sucrose, MCC pellets).

 

起始丸芯无需为球形,但最终产品都是球形

 

The starting pellet core does not need to be spherical, but the final product is always spherical.

 

02.粉末包衣目的 Coating Purpose

 

         增加防潮性 

Increase moisture resistance

在容易分解、潮解的粉末或颗粒外包一 层稳定包衣层,防止粉末或颗粒因含水量或水分而变质。

To coat easily decomposing or deliquescent powders or granules with a stable coating layer to prevent deterioration caused by moisture content or humidity.

改善外观

Improve appearance

湿法离心制粒之后颗粒成球形状,颗粒牢 固性增强,可以与其他组分粒径保持一致, 易于后期混合,美观性提高。

After wet centrifugal granulation, the particles form a spherical shape, their robustness is enhanced, and they can maintain a consistent particle size with other components, making subsequent mixing easier and improving the overall appearance.

提高流动性 

Improve flowability

粉末流动性差,粘附性、凝集性强,在粉末表面包覆一层薄膜后,流动性提高,内聚力降低,便于运输储存。

For powders with poor flowability and strong adhesion or agglomeration, coating their surface with a thin film improves flowability, reduces cohesion, and facilitates transportation and storage.

加遮光性

Increase light-shielding properties

具有极强光敏性药物,暴露在日光和紫外线下可降解为许多光分解产物,包覆例如二氧化钛薄膜后,可以显著降低药物的光降解水平。

For highly photosensitive drugs that can degrade into numerous photolysis products when exposed to sunlight and ultraviolet rays, coating them with a film such as titanium dioxide can significantly reduce the level of photodegradation.

cohesion, and facilitates transportation and storage.

调解释放速度

Regulate the release rate

制备缓释肠溶药物,在粉末或颗粒表面包覆一层隔离层,避免药物对胃的刺激,防止胃酸和胃酶对药物的破坏,并能减少服药的次数,降低不良反应。

To prepare sustained-release enteric-coated drugs, an isolation layer is coated onto the surface of the powder or granules. This prevents gastric irritation caused by the drug, protects it from being destroyed by gastric acid and enzymes, reduces the frequency of administration, and minimizes adverse reactions.

掩盖不良气味

Mask unpleasant odors

在颗粒外层包覆一层稳定的高分子聚合物薄膜(保护衣),提升药物适口性增加颗粒稳定性,且衣层牢固光滑、轻薄。

A stable polymer film (protective coating) is applied to the outer layer of the granules to enhance palatability, increase granule stability, and ensure the coating is strong, smooth, and thin.

 

03.关于我们 About Us

创志科技(江苏)股份有限公司(以下简称“创志科技”)是制药技术整体解决方案服务商,创志科技的企业宗旨是:“勇于创新,追求卓越,创造标准,服务客户”。 

作为中国制剂装备领军企业,创志科技致力于提供高端制药装备的智能化解决方案,产品线包括:固体制剂制粒及缓控释等关键工艺设备,生物制品发酵、纯化、超滤等关键工艺设备,复杂液体制剂均质、乳化、微流控等关键工艺设备,一次性生物技术等关键设备;口服固体制剂连续制造关键设备以及分析软件、控制软件。

创志还参与了国家局的2010版GMP修订,其中负责编写了先进制造及PAT、连续制造、SmartMES等相关内容,参与了药审中心的“化药口服固体制剂连续制造技术指导原则”的起草和审定,创志科技旨在进口替代关键制药核心装备以及创新新的制药技术。

 

Founded in 2004, Chanse is a professional equipment manufacturer dedicated to providing customers with total solutions for solid and liquid dosages and biopharmaceutical. 

We provide full support from process discovery to process transfer to help customers optimize production efficiency and meet market demands. We also provide EMPCV services, including design, build and validation, to provide customers with complete, one-stop attentive services. We focus on continuous innovation and upgrading of process technology to ensure that our customers receive the highest quality products and services. 

In addition, we provide intelligent IT systems and other value-added services to meet the changing needs of our customers. Our professional team will make every effort to provide the best quality and service, continuously expand our company's business, pursue excellence, and create a win-win future.

 

「 联系我们 」

地址:江苏省常州市天宁区劳动东路581号

电话:0519-8550 5268

传真:0519-8886 9251

电子邮箱:sales@chansemt.com

邮编:213000

网址:www.chansemt.com

 

「 Contect Us」

 

Address:No.581 East Labor Road, 

Tianning District, Changzhou City, 

Jiangsu Province, China

Tel:0519-8550 5268

Fax:0519-8886 9251

E-mail: sales@chansemt.com

Zip code: 213000

Website: www.chansemt.com/en